Xyosted (testosterone enanthate) is a brand-name injection prescribed for testosterone deficiency in adults. The cost of the drug, with and without insurance, can depend on several factors, such as whether Xyosted has a savings program.

As with all medications, the cost of Xyosted can vary. Factors that may affect the price you’ll pay include:

  • your treatment plan
  • your insurance coverage
  • the pharmacy you use
  • whether Xyosted has a savings program (see the “Financial and insurance assistance” section below)

To find out what the cost of Xyosted will be for you, talk with your doctor, pharmacist, or insurance provider. Or look below in the next section to learn how much you can save by using an Optum Perks coupon.

To save money on your Xyosted prescription, explore these Optum Perks coupons.

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Retail price refers to the manufacturer’s published list price and is up to date as of 3/2023. Retail and discounted prices are U.S.-only and can vary based on region and pharmacy. We cannot guarantee that the discounted price listed here will exactly match the price at your pharmacy. Please contact your pharmacy for the exact price.

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Here are answers to some frequently asked questions about drug cost and Xyosted.

How does the cost of Xyosted 100 mg vs. 75 mg compare?

The price of the 100-milligram (mg) auto-injector pen may be higher than the price of the 75-mg pen. This is because it contains more of Xyosted’s active ingredient (testosterone enanthate).

Your cost for either strength of Xyosted may also depend on:

  • whether you have insurance or are paying out of pocket
  • the pharmacy you use
  • your treatment plan
  • any savings programs available for the medication

To find out how much Xyosted 100 mg versus 75 mg will cost with insurance, contact your insurance provider. If you don’t have insurance, talk with your doctor or pharmacist or check out Optum Perks. You may also want to contact several pharmacies to compare their prices for Xyosted.

To learn about the recommended dosage of Xyosted for your condition, see this article.

How does Xyosted’s cost compare with that of medications such as testosterone cypionate?

The price you’d pay for Xyosted versus that of testosterone cypionate depends on various factors.

For instance, Xyosted is only available as a brand-name drug. But testosterone cypionate is available as a generic and as the brand-name product Depo-Testosterone. Typically, brand-name drugs cost more than generic drugs. (For details, see the “Brand-name vs. generic drugs” section.)

Other factors that may affect your prescription cost include:

  • whether there are payment assistance programs for your prescribed treatment
  • whether you’re paying out of pocket or have insurance
  • your treatment plan

Both Xyosted and testosterone cypionate are used to treat testosterone deficiency in certain adults. To learn more about the cost of Xyosted compared with other treatments for your condition, talk with your doctor, pharmacist, or insurance provider.

Is Xyosted covered by insurance?

It may be. You can call your insurance provider to learn whether your particular plan covers the cost of this drug.

If you have insurance, your cost for Xyosted depends on factors such as:

  • your particular plan benefits, including your drug copay amount
  • your dosage of the drug
  • whether you apply and qualify for a savings program

You may also need to obtain prior authorization before your plan will cover the cost of this medication (see the “Insurance considerations” section for details).

To learn more about what you’d pay for Xyosted with or without insurance, talk with your doctor, pharmacist, or insurance provider.

You can also visit Optum Perks for price estimates for Xyosted when using coupons from their site. However, Optum Perks coupons cannot be used with insurance benefits or copays. (Optum Perks is a sister site of Medical News Today.)

Xyosted is only available as a brand-name drug. It doesn’t come in a generic version. A generic drug is an exact copy of the active ingredient in a brand-name medication.

Generics tend to cost less than brand-name drugs.

WHY ARE COSTS DIFFERENT FOR BRAND-NAME DRUGS VS. GENERIC DRUGS?

Brand-name drugs can be expensive because of the research needed to test their safety and effectiveness. The manufacturer of a brand-name drug can sell it for up to 20 years. When the brand-name drug’s patent expires, multiple manufacturers can create generic versions. This marketplace competition may lead to lower costs for generics. Also, because generics contain the same active ingredients as brand-name drugs, they don’t require the same costly testing.

If you take Xyosted long term, you may be able to lower its cost in the following ways.

Getting a 3-month supply

You may be able to get a 90-day supply of Xyosted. If approved by your insurance company, getting a 90-day supply of the drug could reduce your number of trips to the pharmacy and help lower the cost. If you’re interested in this option, check with your doctor, pharmacist, or insurance provider.

Using a mail-order pharmacy

Xyosted may be available through a mail-order pharmacy. Using this type of service may help lower the drug’s cost and allow you to receive your medication without leaving home. Some Medicare plans may help cover the cost of mail-order medications. You may also be able to get a 90-day supply of the drug via mail order.

If you don’t have health insurance, talk with your doctor or pharmacist. They may be able to suggest online pharmacy options that could work for you.

If you need financial support to pay for Xyosted, or if you need help understanding your insurance coverage, help is available. For example:

  • A program called Xyosted4You is available for eligible people who don’t have insurance or whose insurance doesn’t cover Xyosted. For more information and to find out whether you’re eligible for support, call 844-996-7833 or visit the program website.
  • The Xyosted Co-pay Assistance Program is available for many people with insurance who need assistance with out-of-pocket costs. For more information and to find out whether you’re eligible for support, call 844-996-7833 or visit the program website.
  • Some websites provide details about drug assistance programs, ways to make the most of your insurance coverage, and links to savings cards and other services. Two such websites are:

To learn more about saving money on prescriptions with or without insurance, check out this article.

Below is information you may want to consider if you have insurance and receive Xyosted.

If you have insurance, your insurance company may require prior authorization before it covers Xyosted. This means the company and your doctor will discuss Xyosted in regard to your treatment. The insurance company will then determine whether the medication is covered.

If a drug requires prior authorization but you start treatment without the prior approval, you could pay the full cost of the medication. You can ask your insurance company whether Xyosted requires prior authorization.

For more information about testosterone deficiency and related health and wellness conditions, explore our men’s health hub.

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.