Xhance (fluticasone propionate)

Xhance generic

Xhance is a brand-name drug that contains the active ingredient fluticasone propionate. This active ingredient is also available as a generic medication. A generic drug is an exact copy of the active ingredient in a brand-name medication.

The generic is considered to be as safe and effective as the original drug. Generics tend to cost less than brand-name drugs.

Note that generic nasal sprays containing fluticasone propionate are not exact copies of Xhance. They contain a different strength of fluticasone propionate than Xhance and are used in a different way. With generic nasal sprays, you sniff the drug into your nasal passages. But Xhance nasal spray has a mouthpiece that you use to blow the drug through a nosepiece into your nasal passages. To learn more about how to use Xhance, see the “Xhance dosage” section.

If you’re interested in using a generic fluticasone nasal spray, talk with your doctor. They can tell you if it can be used for your condition.

Xhance cost and coupons

As with all medications, the cost of Xhance can vary. The actual price you’ll pay depends on your insurance plan, your location, and the pharmacy you use.

Drug coupons: You can visit Optum Perks for price estimates of Xhance. These estimates are based on the use of Optum Perks coupons. Note: Optum Perks coupons cannot be used with any insurance copays or benefits.

Financial and insurance assistance: If you need financial support to pay for Xhance, or if you need help understanding your insurance coverage, help is available. A patient assistance program is available for Xhance. For more information and to find out if you’re eligible for support, call 833-942-6231 or visit the program website.

Generic version: Xhance is available in a generic form called fluticasone propionate nasal spray. A generic drug is an exact copy of the active ingredient in a brand-name medication. The generic is considered to be as safe and effective as the original drug. And generics tend to cost less than brand-name drugs. To find out how the cost of fluticasone propionate nasal spray compares to the cost of Xhance, talk with your doctor or pharmacist.

Note that generic nasal sprays containing fluticasone propionate are not exact copies of Xhance. They contain a different strength of fluticasone propionate than Xhance and are used in a different way. With generic nasal sprays, you sniff the drug into your nasal passages. But Xhance nasal spray has a mouthpiece that you use to blow the drug through a nosepiece into your nasal passages. To learn more about how to use Xhance, see the “Xhance dosage” section.

To learn more about saving money on prescriptions, check out this article.

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Retail price refers to the manufacturer’s published list price and is up to date as of 3/2023. Retail and discounted prices are U.S.-only and can vary based on region and pharmacy. We cannot guarantee that the discounted price listed here will exactly match the price at your pharmacy. Please contact your pharmacy for the exact price.

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Xhance side effects

Xhance can cause mild or serious side effects. The following lists contain some of the key side effects that may occur while using Xhance. These lists do not include all possible side effects.

For more information about the possible side effects of Xhance, talk with your doctor or pharmacist. They can give you tips on how to manage any side effects that may be concerning or bothersome.

Note: The Food and Drug Administration (FDA) tracks side effects of drugs it has approved. If you would like to notify the FDA about a side effect you’ve had with Xhance, you can do so through MedWatch.

Mild side effects

Below is a partial list of mild side effects of Xhance. To learn about other mild side effects, talk with your doctor or pharmacist, or view Xhance’s prescribing information.

Mild side effects of Xhance can include:

• nosebleeds
• stuffy nose
• ulcers (sores) in the nose
• soreness or swelling in the nose or throat
• redness in the nose
• sinus infection
• fungal infection in the nose, mouth, or throat
• headache

Most of these side effects may go away within a few days to a couple of weeks. However, if they become more severe or don’t go away, talk with your doctor or pharmacist.

Serious side effects

Serious side effects from Xhance aren’t common, but they can occur. Call your doctor right away if you have serious side effects. Call 911 or your local emergency number if your symptoms feel life threatening or you think you’re having a medical emergency.

Serious side effects and their symptoms can include:

• perforated nasal septum (hole in the cartilage that separates your nostrils), which may include symptoms such as:
  • whistling sound when breathing through your nose
• eye problems, such as glaucoma or cataracts, which may cause vision changes such as:
  • blurry vision
  • loss of peripheral vision
  • seeing haloes around lights
  • trouble with night vision
• Cushing syndrome, which may include symptoms such as:
  • weight gain
  • thinning skin
  • bruising easily
• adrenal suppression (reduced production of cortisol by the adrenal glands), which may include symptoms such as:
  • feeling weak or tired
  • dizziness
  • nausea and vomiting
• increased risk of infection, which may include symptoms such as:
  • fever or chills
  • aches and pains
  • cough
• weakened bones, which may include symptoms such as:
  • unusual bone fractures, such as with a minor knock or fall

ALLERGIC REACTION

For some people, Xhance nasal spray can cause an allergic reaction. In general, symptoms of allergic reaction can be mild or serious.

Ways to manage

For mild allergic reaction symptoms, such as a mild rash, call your doctor right away. They may recommend treatments to help manage your symptoms. They’ll also let you know whether you should keep using the medication.

For severe allergic reaction symptoms, such as swelling or trouble breathing, call 911 or your local emergency number right away. These symptoms require immediate medical care because they can become life threatening. If you’ve had a serious allergic reaction to Xhance nasal spray, your doctor may recommend a different medication instead.

Common questions about Xhance

Here are answers to some frequently asked questions about Xhance.

How does Xhance compare with Flonase?

Xhance and Flonase are both nasal sprays that contain the same active drug, fluticasone propionate. However, there are several differences between these medications.

For example, Xhance contains a different strength of fluticasone propionate than Flonase and is used in a different way. With Flonase nasal spray, you sniff the drug into your nasal passages. But Xhance nasal spray has a mouthpiece that you use to blow the drug through a nosepiece into your nasal passages. This may allow more of the medication to reach deep into your nasal passages and less may drip down the back of your throat.

Xhance is used to treat chronic (ongoing) rhinosinusitis with or without nasal polyps. It’s only available with a prescription.

Flonase allergy relief is an over-the-counter nasal spray used to treat nasal allergies, such as hay fever. A prescription version of Flonase nasal spray was previously available for treating nasal inflammation not caused by allergies. But this product has been discontinued by the manufacturer.

If you have more questions about Xhance versus Flonase, talk with your doctor or pharmacist. They can recommend whether one of these drugs is more suitable for you.

How does Xhance work?

Xhance is used to treat chronic rhinosinusitis with or without nasal polyps. With chronic rhinosinusitis, you have ongoing inflammation (swelling) in your nasal passages and sinuses. The inflammation can cause polyps, which are small, noncancerous growths in the lining of your nasal passages and sinuses. These conditions can cause symptoms such as nasal and facial pain, stuffy or runny nose, and a reduced sense of smell.

Xhance contains the active drug fluticasone propionate, which is a type of drug called a corticosteroid. It works by reducing the inflammation in your nasal passages and sinuses. It also helps shrink nasal polyps. This helps relieve the pain, congestion, and other symptoms associated with these conditions.

Talk with your doctor to learn more about how Xhance works.

Xhance dosage

The following information describes Xhance dosages that are commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to fit your needs.

Drug form and strength

Xhance comes as a nasal spray. Each spray delivers 93 micrograms (mcg) of the active drug fluticasone propionate.

Only one strength of Xhance is available.

Dosage for chronic rhinosinusitis with or without nasal polyps

The recommended dosage of Xhance is 186 mcg (one spray in each nostril) or 372 mcg (two sprays in each nostril) twice daily.

The maximum recommended dosage is two sprays in each nostril twice daily.

How to use

Xhance nasal spray is used in a different way than traditional nasal sprays. The Xhance nasal spray device has a mouthpiece that you use to blow the medication through a nosepiece into your nasal passages.

To take a dose, you insert the nosepiece into one nostril so that it makes a tight seal with your nostril. You then place the flexible mouthpiece in your mouth. You blow into the mouthpiece while pushing the bottle up to activate the dose. Your breath carries the dose deep into your nasal passages. You should not sniff or breath in or out through your nose while you are taking a dose.

Your doctor or pharmacist can show you how to use Xhance nasal spray correctly. For more details, you can view the instructions provided with the nasal spray. The manufacturer’s website also has a step-by-step instruction video.

About using Xhance

Below you’ll find information about key dosage issues.

• When to use: You should use Xhance twice per day, morning and evening. Using the medication around the same time of day helps keep a steady level of the drug in your body. This helps Xhance work effectively.
• If you miss a dose: If you miss a dose, take it as soon as you remember that day. If you don’t remember until the following day, skip the missed dose. Do not take more than your prescribed dose each day.
• Length of treatment: Xhance is meant to be used as a long-term treatment. If you and your doctor determine that Xhance is safe and effective for you, you’ll likely use it long term.
• Length of time to work: How long Xhance takes to work can vary between people. For some people, the drug may start to relieve symptoms after 2 weeks, but for others, it may take longer than this. Be sure to keep using Xhance regularly, even if your symptoms don’t improve at first.

Overdose

Do not use more Xhance than your doctor recommends. For some drugs, doing so may lead to unwanted side effects or overdose.

What to do in case you use too much Xhance

If you think you’ve used too much of this drug, call your doctor. You can also call America’s Poison Centers at 800-222-1222 or use its online tool. However, if your symptoms are severe, call 911 or your local emergency number, or go to the nearest emergency room right away.

Similar drugs

Other drugs are available that can treat your condition. Some may be a better fit for you than others. If you’re interested in finding an alternative to Xhance, talk with your doctor. They can tell you about other medications that may work well for you.

The following drugs are similar to Xhance:

• beclomethasone dipropionate (QNasl)
• budesonide (Rhinocort allergy)
• fluticasone propionate (Flonase allergy relief)
• mometasone furoate (Nasonex 24hr allergy)

Xhance uses

The Food and Drug Administration (FDA) approves prescription drugs such as Xhance to treat certain conditions. Xhance may also be used off-label for other conditions. Off-label drug use is when an FDA-approved drug is prescribed for a purpose other than what it’s approved for.

Xhance for chronic rhinosinusitis

Xhance is FDA approved to treat chronic (ongoing) rhinosinusitis with or without nasal polyps in adults. Chronic rhinosinusitis is sometimes just called chronic sinusitis.

Chronic rhinosinusitis is inflammation (swelling) in your nasal passages and sinuses that lasts 3 months or longer. It can cause nasal polyps, which are small, noncancerous growths that develop in the linings of your nasal passages and sinuses. Both conditions can cause symptoms such as:

• pain and pressure along the sides of the nose, behind the cheeks, and above the eyes
• stuffy or blocked nose
• yellow or green mucus draining from the nose
• runny nose or feeling of mucus running down the back of the throat
• reduced sense of smell
• trouble sleeping

Xhance is prescribed to reduce swelling in the nasal passages and sinuses, which helps relieve the symptoms of these conditions.

Xhance and children

Xhance is not FDA approved for any uses in children under 18 years old. The manufacturer has not studied the medication in this age group.

Xhance interactions

Xhance can interact with several other medications. It can also interact with certain supplements as well as certain foods.

Before using Xhance, talk with your doctor and pharmacist. Tell them about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you use. Sharing this information can help you avoid potential interactions.

Interactions with medications, foods, and supplements

Below is a list of medications, supplements, and foods that can interact with Xhance. This list does not contain all drugs that may interact with Xhance. If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.

Alcohol interaction

Alcohol is not known to interact with Xhance. It’s likely safe to consume alcohol while using Xhance. If you have questions about how much alcohol is safe to drink while using Xhance, talk with your doctor or pharmacist.

Things to consider when using Xhance

If you can become pregnant, consider the following information about pregnancy, fertility, birth control, and breastfeeding.

Xhance and pregnancy

It’s not known whether Xhance should be used during pregnancy. If you’re planning a pregnancy or can become pregnant, talk with your doctor before using this medication.

Xhance and birth control

It’s not known if Xhance is safe to use during pregnancy. If you’re sexually active and you or your partner can become pregnant, talk with your doctor about your birth control needs while you’re using Xhance.

Xhance and breastfeeding

It’s not known whether Xhance should be used while breastfeeding. If you’re currently breastfeeding or planning to do so, talk with your doctor before using this medication.