Vyvgart Hytrulo is a brand-name liquid solution for infusion. It’s prescribed for certain autoimmune conditions. Vyvgart Hytrulo contains the active ingredients efgartigimod alfa and hyaluronidase-qvfc.
Vyvgart Hytrulo is FDA approved to treat the following autoimmune conditions in certain adults:
Drug details
You’ll find key information about Vyvgart Hytrulo below.
- Drug class: neonatal Fc receptor blocker and endoglycosidase
- Drug form: liquid solution given as a subcutaneous infusion (injection given over time)
- Generic or biosimilar available? no
- Prescription required? yes
- Controlled substance? no
- Year of FDA approval: 2023
Vyvgart Hytrulo is a brand-name biologic drug. It’s not available in biosimilar form.
While traditional drugs are made using chemicals, biologics are made using parts of living cells. This allows traditional drugs to have generics that are exact copies of the brand-name form. However, biologics have biosimilars instead of generics because they cannot be copied exactly.
As with generics, biosimilars are considered to be as safe and effective as the original brand-name drug.
As with all medications, the cost of Vyvgart Hytrulo can vary. The actual price you’ll pay depends on your insurance plan and your location.
Drug coupons: You can visit Optum Perks for price estimates of Vyvgart Hytrulo. These estimates are based on the use of Optum Perks coupons. Note: Optum Perks coupons cannot be used with any insurance copays or benefits.
Financial and insurance assistance: If you need financial support to pay for Vyvgart Hytrulo or you need help understanding your insurance coverage, help is available.
A program called My Vygart Path is available for Vyvgart Hytrulo. For more information and to find out if you’re eligible for support, call 833-898-4278 or visit the program website.
Generic or biosimilar version: Vyvgart Hytrulo is not available in a biosimilar form. It’s a biologic drug made from parts of living cells. Instead of generics, biologics have biosimilars because they cannot be copied exactly. Traditional drugs are made using chemicals. This allows traditional drugs to have generics that are exact copies of the active ingredient in the brand-name medication.
As with generics, biosimilars are considered to be as safe and effective as the original brand-name drug. And they may cost less than brand-name drugs.
To learn more about saving money on prescriptions, check out this article.
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The following information describes dosages of Vyvgart Hytrulo that doctors commonly use or recommend. However, your doctor will determine the best dosage to fit your needs.
Drug form and strength
Vyvgart Hytrulo comes as a liquid solution in a single-use vial. It’s available in one strength: 1,008 milligrams (mg) of efgartigimod alfa and 11,200 units of hyaluronidase in 5.6 milliliters (mL) of solution.
Dosage for gMG
For generalized myasthenia gravis (gMG), the typical dose is 1,008 mg/11,200 units (one vial) per infusion. You’ll receive one infusion of Vyvgart Hytrulo each week for 4 weeks.
Your doctor may recommend additional 4-week treatment cycles for gMG, depending on your response to the treatment. They’ll likely wait at least 50 days between each treatment cycle.
Dosage for CIDP
For chronic inflammatory demyelinating polyneuropathy (CIDP), the typical dose is 1,008 mg/11,200 units (one vial) per infusion. You’ll receive one infusion of Vyvgart Hytrulo each week.
Your doctor can tell you how long you’ll receive Vyvgart Hytrulo for CIDP.
How it’s given
Your doctor or a healthcare professional will give Vyvgart Hytrulo as a subcutaneous infusion (an injection that’s given under your skin over a period of time). Each infusion is typically given over 30 to 90 seconds.
You’ll receive Vyvgart Hytrulo in a clinic, doctor’s office, or infusion center. In some cases, you may receive infusions of Vyvgart Hytrulo at home.
If you have other questions about receiving Vyvgart Hytrulo, talk with your doctor. You can also visit the drug manufacturer’s website for gMG or CIDP.
About receiving Vyvgart Hytrulo
Below you’ll find information about key dosage issues.
- When you’ll receive it: You’ll receive Vyvgart Hytrulo infusion once per week based on your condition.
- If you miss a dose: If you miss an appointment for your Vyvgart Hytrulo infusion, call the clinic, doctor’s office, or infusion center right away to reschedule.
- Length of use: The length of time you’ll receive Vyvgart Hytrulo depends on your condition and how you respond to the treatment. Your doctor will determine how long you’ll receive the drug.
- Length of time to work: Vyvgart Hytrulo starts to work after your first dose. Your doctor will monitor the symptoms of your condition to determine how well the drug is working. They’ll advise you on how your condition is responding to Vyvgart Hytrulo.
Vyvgart Hytrulo can cause mild or serious side effects. The following lists contain some key side effects that may occur while receiving Vyvgart Hytrulo. These lists do not include all possible side effects.
For more information about the possible side effects of Vyvgart Hytrulo, talk with your doctor or pharmacist. They can give you tips on how to manage any side effects that may be concerning or bothersome.
Note: The Food and Drug Administration (FDA) tracks side effects of drugs it has approved. If you would like to notify the FDA about a side effect you’ve had with Vyvgart Hytrulo, you can do so through MedWatch.
Mild side effects
Below is a partial list of mild side effects of Vyvgart Hytrulo. To learn about other mild side effects, talk with your doctor or pharmacist, or view Vyvgart Hytrulo’s prescribing information.
Mild side effects of Vyvgart Hytrulo can include:
- headache
- low levels of white blood cells
- mild infection, such as urinary tract infection (UTI) or respiratory tract infection
- muscle pain
- numbness, burning, or tingling in your mouth, hands, or feet
- reactions around the infusion site, such as bruising, discoloration, or pain
Most of these side effects may go away within a few days to a couple of weeks. However, if they become more severe or don’t go away, talk with your doctor or pharmacist.
Serious side effects
Serious side effects from Vyvgart Hytrulo aren’t common, but they can occur. Call your doctor right away if you have serious side effects. Call 911 or your local emergency number if your symptoms feel life threatening or you think you’re having a medical emergency.
Serious side effects can include infusion reactions, which may cause symptoms such as:
- abdominal pain
- back pain
- chills
- low blood pressure
ALLERGIC REACTIONFor some people, Vyvgart Hytrulo can cause an allergic reaction. In general, symptoms of an allergic reaction can be mild or serious.
Ways to manage
For mild allergic reaction symptoms, such as a mild rash, call your doctor right away. They may recommend treatments to help manage your symptoms. They’ll also let you know whether you should keep receiving the medication.
For severe allergic reaction symptoms, such as swelling or difficulty breathing, call 911 or your local emergency number right away. These symptoms require immediate medical care because they can become life threatening. If you’ve had a serious allergic reaction to Vyvgart Hytrulo, your doctor may recommend a different medication instead.
The Food and Drug Administration (FDA) approves prescription drugs such as Vyvgart Hytrulo to treat certain conditions.
Vyvgart Hytrulo for gMG
Vyvgart Hytrulo is approved to treat generalized myasthenia gravis (gMG) in certain adults.
gMG is a condition that causes muscle weakness. “Generalized” means that muscles throughout the body may be affected. Other symptoms may include fatigue, blurred vision, and difficulty breathing, speaking, or swallowing.
Vyvgart Hytrulo can be prescribed for adults who have specific antibodies (a type of protein) in their blood. These antibodies target attachment sites called acetylcholine receptors (AChR). Antibodies targeting AChR are thought to cause the symptoms of gMG.
To learn more about Vyvgart Hytrulo for gMG, talk with your doctor.
Vyvgart Hytrulo for CIDP
Vyvgart Hytrulo is approved to treat chronic inflammatory demyelinating polyneuropathy (CIDP) in adults.
With CIDP, the immune system mistakenly attacks myelin, which is the protective covering that surrounds the nerves outside of the brain and spinal cord. This can cause inflammation and nerve damage, typically in the arms and legs. Symptoms may include difficulty walking and numbness, pain, or tingling in the arms or legs.
To learn more about Vyvgart Hytrulo for CIDP, talk with your doctor.
Vyvgart Hytrulo and children
Vyvgart Hytrulo is not FDA-approved for use in children. It’s not known for certain whether the drug is safe or effective for children.
Vyvgart Hytrulo can interact with several other medications. It’s not known to interact with supplements or foods.
Before receiving Vyvgart Hytrulo, talk with your doctor and pharmacist. Tell them about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you use. Sharing this information can help you avoid potential interactions.
Interactions with medications
Below is a list of medications that can interact with Vyvgart Hytrulo. This list does not contain all drugs that may interact with Vyvgart Hytrulo. If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.
| Medications that can interact with Vyvgart Hytrulo | • monoclonal antibodies, such as belimumab (Benlysta) and rituximab (Rituxan) • intravenous immunoglobulin (IVIg) |
|---|---|
| Vaccines that can interact with Vyvgart Hytrulo | • live vaccines, such as the measles, mumps, and rubella (MMR) vaccine and the nasal spray flu vaccine (FluMist) |
Alcohol interaction
Alcohol is not known to interact with Vyvgart Hytrulo. It’s likely safe to consume alcohol while you’re receiving Vyvgart Hytrulo.
If you have questions about how much alcohol is safe to drink during treatment with Vyvgart Hytrulo, talk with your doctor or pharmacist.
Other drugs are available for myasthenia gravis (MG) and chronic inflammatory demyelinating polyneuropathy (CIDP). Some may be a better fit for you than others. If you’re interested in finding an alternative to Vyvgart Hytrulo, talk with your doctor. They can tell you about other medications that may work well for you.
Examples of drugs that are alternatives to Vyvgart Hytrulo include:
- eculizumab (Soliris)
- efgartigimod alfa-fcab (Vyvgart)
- ravulizumab-cwvz (Ultomris)
- rozanolixizumab (Rystiggo)
- intravenous immunoglobulin (IVIg)
If you can become pregnant, consider the following information about pregnancy and breastfeeding.
Vyvgart Hytrulo and pregnancy
It’s not known whether Vyvgart Hytrulo should be given during pregnancy. If you’re planning a pregnancy or can become pregnant, talk with your doctor before receiving this medication.
If you’re prescribed Vyvgart Hytrulo during pregnancy, consider joining the drug’s pregnancy registry. This registry collects information about how the drug may affect pregnancy. To learn more, call 855-272-6524 or visit the registry website.
Vyvgart Hytrulo and breastfeeding
It’s not known whether Vyvgart Hytrulo should be given while breastfeeding. If you’re currently breastfeeding or planning to do so, talk with your doctor before receiving this medication.
This drug comes with several precautions.
Before starting treatment with Vyvgart Hytrulo, discuss your health history with your doctor. Vyvgart Hytrulo may not be right for you if you have certain medical conditions or other factors affecting your health. Be sure to talk with your doctor if any of the following apply to you:
- current infection
- previous allergic reaction to this or a similar drug
- pregnancy
- breastfeeding
Note: For more information about the potential negative effects of Vyvgart Hytrulo, see the “Vyvgart Hytrulo side effects” section.
Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.