Kisunla (donanemab-azbt) is a brand-name injection for IV infusion prescribed for Alzheimer’s disease. Kisunla has no known interactions with alcohol, other drugs, or supplements. However, the drug has health-related interactions.

An interaction occurs when one substance causes another substance to have a different effect than expected.

To learn more about Kisunla’s interactions, keep reading. For additional information about Kisunla, including details about its uses, see this article.

Note: As a person’s condition progresses, they may need help reading or understanding information regarding their circumstances. This article contains details that may help caregivers learn more about Kisunla.

Kisunla isn’t known to interact with other medications. However, it’s possible that new interactions may be recognized in the future. For example, people who’ve received Kisunla since it became available could report a suspected interaction.

Before you start treatment with Kisunla, tell your doctor and pharmacist which prescription, over-the-counter, and other medications you take. By sharing this information with them, you may help prevent possible interactions. (To learn whether Kisunla interacts with supplements, herbs, or vitamins, see the “Kisunla and other interactions” section.)

If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.

Sometimes, factors or conditions could prevent your doctor from prescribing Kisunla due to the risk of harm. These are known as contraindications. The contraindications of Kisunla include:

Having had an allergic reaction to Kisunla or any of its ingredients

If you have had an allergic reaction to Kisunla or any of its ingredients, your doctor will likely not prescribe Kisunla. Taking the drug could cause another allergic reaction. You can ask them about other treatments that may be better choices for you.

Note: Before you start treatment with Kisunla, it’s important to tell your doctor if this contraindication applies to you. They can determine whether to prescribe Kisunla.

There aren’t any known interactions between Kisunla and alcohol.

However, your doctor may advise you to avoid or limit alcohol consumption during Kisunla treatment. This is because consuming large amounts of alcohol can worsen Alzheimer’s disease, which Kisunla is used to treat.

If you have questions about drinking alcohol during Kisunla treatment, talk with your doctor.

Kisunla may have other interactions, such as with supplements, foods, vaccines, or even lab tests. You’ll find details below. Keep in mind that the following information does not include all other possible interactions with Kisunla.

Kisunla and supplements

It’s possible for drugs to interact with supplements such as vitamins and herbs.

Kisunla and herbs

There are no specific reports of herbs interacting with Kisunla. However, that doesn’t mean herbal interactions won’t occur or be recognized in the future. Because of this, it’s important to check with your doctor or pharmacist before taking any of these products during Kisunla treatment.

Kisunla and vitamins

There are no specific reports of vitamins interacting with Kisunla. However, that doesn’t mean vitamin interactions won’t occur or be recognized in the future. Because of this, you should talk with your doctor or pharmacist before taking any vitamin product with Kisunla.

Kisunla and food

There were no reports of food interactions with Kisunla. If you’d like to learn more about eating certain foods during treatment with Kisunla, talk with your doctor.

Kisunla and vaccines

There aren’t any known interactions between Kisunla and vaccines. Talk to your doctor or pharmacist to see whether you’re due for any vaccines.

Kisunla and lab tests

Kisunla isn’t known to interact with any lab tests. If you have concerns about this medication interacting with lab tests, talk to your doctor.

KISUNLA AND CANNABIS OR CBD

Cannabis (often called marijuana) and cannabis products, such as cannabidiol (CBD), have not been specifically reported to interact with Kisunla. However, as with any drug or supplement, talk with your doctor before using cannabis in combination with Kisunla. The impact of cannabis may affect how well you stick to your Kisunla treatment plan.

Note: Cannabis is illegal at a federal level but is legal in many states to varying degrees.

Certain medical conditions and other factors may increase the risk of interactions with Kisunla. Before you take this drug, be sure to talk with your doctor about your health history. Kisunla may not be the right treatment option if you have certain medical conditions or other factors affecting your health.

Health conditions or factors that might interact with Kisunla include:

  • Allergic reaction: If you’ve had an allergic reaction to Kisunla or any of its ingredients, your doctor will likely not prescribe Kisunla. Taking the drug could cause another allergic reaction. You can ask them about other treatments that may be better choices for you.
  • Breastfeeding: It is unknown whether it’s safe to receive Kisunla while breastfeeding. There isn’t enough information to determine whether the drug passes into breast milk or what effects Kisunla may have on a child who is breastfed. If you’re breastfeeding or planning to, talk with your doctor before using Kisunla. They can talk with you about treatment options and ways to feed your child.
  • Pregnancy: There haven’t been enough clinical trials to determine whether Kisunla is safe to receive while pregnant. If you’re pregnant or planning to become pregnant, tell your doctor before starting Kisunla. They can advise you on the right treatment plan for you.
  • Risk of amyloid-related imaging abnormalities (ARIA): Kisunla has a boxed warning about the risk of ARIA. This is a serious warning from the Food and Drug Administration (FDA). A boxed warning alerts doctors and patients about drug effects that may be dangerous. For details, see the boxed warning at the top of this article.

You can take certain steps to help prevent interactions with Kisunla. Your doctor and pharmacist are key resources, so reach out to them before starting treatment. For example, you should plan to do the following:

  • Let them know if you drink alcohol or use cannabis.
  • Tell them about any other medications you take, as well as any supplements, herbs, and vitamins.
  • Create a medication list, which your doctor and pharmacist can help you fill out.
  • Consider helping to collect more information about Kisunla by enrolling in the registry to learn more about Alzheimer’s disease and treatments. To enroll, call 800-LillyRx (800-545-5979).

It’s also important to read the Kisunla label and other paperwork that may come with the drug. The label may have colored stickers that mention an interaction. And the paperwork, sometimes called the medication guide or patient package insert, may contain details about interactions.

If Kisunla doesn’t come with paperwork, you can ask your pharmacist to print a copy. If you need help reading or understanding this information, ask your doctor or pharmacist.

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.