Estrogen Deficiency Causes Bladder Hypersensitivity Via Upregulation C-Fiber Bladder Afferent Nerves

Main Category: Urology / Nephrology
Also Included In: Endocrinology;  Women's Health / Gynecology
Article Date: 27 Jun 2008 - 4:00 PDT

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ORLANDO, FL (UroToday.com) - Dr. Kazuya Tanase and colleagues from Fukui, Japan demonstrated that estrogen deficiency may cause up-regulation of C-fiber afferent activity from the bladder that can result in bladder hypersensitivity.

Furthermore, based on previous reports of estrogen deficiency being related to a decrease in spinal serotonin receptors, they demonstrated evidence that the increased hypersensitivity of the bladder following ovariectomy may be related to changes in the serotonin receptor system in the spine.

Presented by Kazuya Tanase, MD, at the Annual Meeting of the American Urological Association (AUA) - May 17 - 22, 2008. Orange County Convention Center - Orlando, Florida, USA.

Reported by UroToday.com Contributing Editor Kathleen C. Kobashi, MD

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