A New Cause Of Male Infertility After Cisplatin Exposure: The Effect Of Cisplatin On Y Chromosomes

Main Category: Urology / Nephrology
Also Included In: Fertility
Article Date: 26 Jun 2008 - 0:00 PDT

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ORLANDO, FL (UroToday.com) - The authors demonstrate that the widely employed chemotherapeutic agent Cisplatin (CP) based chemotherapy effects TSPY gene activity. A reverse transcription-polymerase chain reaction (RT-PCR) was employed to determine the expression of mRNA for TSPY and immunohistochemical staining for histone 2B (H2B) were performed on the rat testes of animals exposed to CP. There appeared to be a dose related effect on the expression of TSPY mRNA levels. Immunohistochemical analysis revealed that H2B expression was decreased in a dose dependent manner as a result of the destruction of DNA and chromosomes after exposure to CP.

Editorial Comment: This would support the notion that the infertility resulting from CISPLATINUM chemotheraoy may at least be partially explained in the basis of genetic alterations on the Y chromosome.

Presented byCem Akbal, MD, Polat Turker, MD, Mustafa Ozyurek, MD, Gozde Erkanli, MD, Ferruh Simsek, MD, and Levent Turkeri, MD, at the Annual Meeting of the American Urological Association (AUA) - May 17 - 22, 2008. Orange County Convention Center - Orlando, Florida, USA.

Reported by UroToday.com Contributing Editor Harris M. Nagler, MD

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